249. [I. 2. b.]

SYNTHESIS OF SOME IMIDAZO [ I , 2-b] [l , 2,4] TRIAZINE AND N-ALKYLATED IMIDAZO [l , 2-b] [1 , 2,4]-TRIAZINES

A number of 3-amino-1, 2, 4-triazin-5 (2H)- ones(1) were synthesized and condensed with a-haloketones to give 2,6-disubstituted imidazo [1, 2-b] [1, 2, 4]-triazin-3 (4H)-ones (2). These compounds were reacted further with a - haloketones to yield N-alkylated products (3).

Abstract 249

Session Information for Program Number 249 Print Close window Abstract Content Program Nr: Mutant phenotypes of the microRNA genes of . , Ezequiel Alvarez-Saavedra , Allison Abbott , Nelson Lau , David P. Bartel , Victor Ambros , Bob Horvitz . 1) HHMI, Dept. Biology, MIT, Cambridge, MA 02139, USA; 2) Dept. Genetics, Dartmouth Medical School, Hanover, NH 03755, USA; 3) Whitehead Institute for Bi...

2-absorbing $I$-prime and 2-absorbing $I$-second submodules

Let $R$ be a commutative ring and let $I$ be an ideal of $R$. In this paper, we will introduce the notions of 2-absorbing $I$-prime and 2-absorbing $I$-second submodules of an $R$-module $M$ as a generalization of 2-absorbing and strongly 2-absorbing second submodules of $M$ and explore some basic properties of these classes of modules.

Math 249: Algebraic Combinatorics

Dmd055400 245..249

Amlodipine is a commonly prescribed calcium channel blocker for the treatment of hypertension and ischemic heart disease. The drug is slowly cleared in humans primarily via dehydrogenation of its dihydropyridine moiety to a pyridine derivative (M9). Results from clinical drug-drug interaction studies suggest that CYP3A4/5 mediate metabolism of amlodipine. However, attempts to identify a role of...